X0306 4 2020-08-18 0 0001346302 XERIS PHARMACEUTICALS INC XERS 0001553595 Shannon John Patrick Jr C/O XERIS PHARMACEUTICALS, INC. 180 N. LASALLE STREET, SUITE 1600 CHICAGO IL 60601 0 1 0 0 See Remarks Common Stock 121224 D Stock Option (right to buy) 4.29 2020-08-18 4 A 0 100000 0.00 A 2030-08-18 Common Stock 100000 100000 D 25% of these shares shall vest on the first anniversary of the vesting commencement date, with the remainder vesting ratably over the following 36 months, in all cases subject to Mr. Shannon's continuous service to the company through each vesting date. President and Chief Operating Officer /s/ Beth Hecht, as Attorney-in-Fact 2020-08-20