X0306 4 2020-02-14 0 0001346302 XERIS PHARMACEUTICALS INC XERS 0001531178 Edick Paul R C/O XERIS PHARMACEUTICALS, INC. 180 N. LASALLE STREET, SUITE 1600 CHICAGO IL 60601 1 1 0 0 See Remarks Common Stock 2020-02-14 4 P 0 20000 4.15 A 183134 D Common Stock 13430 I By: Paul R. Edick 2008 Revocable Trust u/d/t dated 6/25/2018 Represents shares purchased in an underwritten public offering of the Issuer at the public offering price of $4.15 per share. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. Chairman, President & Chief Executive Officer /s/ Beth Hecht, as Attorney-in-Fact 2020-02-18