X0306 4 2020-01-31 0 0001346302 XERIS PHARMACEUTICALS INC XERS 0001531178 Edick Paul R C/O XERIS PHARMACEUTICALS, INC. 180 N. LASALLE STREET, SUITE 1600 CHICAGO IL 60601 1 1 0 0 See Remarks Common Stock 2020-01-31 4 F 0 9801 6.37 D 163134 D Common Stock 13430 I By: Paul R. Edick 2008 Revocable Trust u/d/t dated 6/25/2018 These shares were withheld by the issuer to satisfy statutory tax withholding requirements on vesting of restricted stock units. The number of shares to be withheld was determinable on January 31, 2020. No shares were sold in connection with this transaction. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. Chairman, President & Chief Executive Officer /s/ Beth Hecht, as Attorney-in-Fact 2020-02-04