X0306 4 2019-12-31 0 0001346302 XERIS PHARMACEUTICALS INC XERS 0001652410 Hecht Beth C/O XERIS PHARMACEUTICALS, INC. 180 N. LASALLE STREET, SUITE 1600 CHICAGO IL 60601 0 1 0 0 See Remarks Common Stock 2019-12-31 5 A 0 E 459 5.99 A 4083 D These shares were purchased due to participation by the reporting individual in the issuer's 2018 Employee Stock Purchase Plan ("ESPP"). It pertains to the ESPP purchase period from July 1, 2019 through December 31, 2019. In accordance with the ESPP, these shares were purchased based on 85% of the closing price of the issuer's common stock on December 31, 2019. Senior Vice President, General Counsel and Corporate Secretary /s/ Beth Hecht 2020-01-06