X0306 4 2019-02-19 0 0001346302 XERIS PHARMACEUTICALS INC XERS 0001652410 Hecht Beth C/O XERIS PHARMACEUTICALS, INC. 180 N. LASALLE STREET, SUITE 1810 CHICAGO IL 60601 0 1 0 0 See Remarks Common Stock 2019-02-19 4 P 0 2500 10.00 A 2500 D Ms. Hecht purchased shares of common stock from the underwriters in a public offering pursuant to the registrant's Registration Statement on Form S-1 (File No. 333-229665, completed on February 19, 2019). The shares of common stock were purchased at the public offering price. Senior Vice President, General Counsel and Corporate Secretary /s/ Beth Hecht 2019-02-22