X0206 3 2019-01-01 0 0001346302 XERIS PHARMACEUTICALS INC XERS 0001652410 Hecht Beth C/O XERIS PHARMACEUTICALS, INC. 180 N. LASALLE STREET, SUITE 1810 CHICAGO IL 60601 0 1 0 0 See Remarks Stock Option (Right to Buy) 5.93 2028-01-30 Common Shares 30879 D Stock Option (Right to Buy) 12.50 2028-05-14 Common Shares 30802 D Stock Option (Right to Buy) 12.50 2028-05-14 Common Shares 34493 D Stock Option (Right to Buy) 19.00 2028-10-04 Common Shares 3826 D 25% of the shares shall vest on January 16, 2019, and the remaining 75% of the shares shall vest in 36 equal monthly installments on the sixteenth day of each month thereafter. 25% of the shares shall vest on May 15, 2019, and the remaining 75% of the shares shall vest in 36 equal monthly installments on the fifteenth day of each month thereafter. 25% of the shares shall vest on October 5, 2019, and the remaining 75% of the shares shall vest in 36 equal monthly installments on the fifth day of each month thereafter. These options are early exercisable. Senior Vice President, General Counsel and Corporate Secretary Exhibit 24.1: Power of Attorney attached /s/ Beth Hecht 2018-01-09