<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:ns1="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001085146-22-000567</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001345929</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>4</amendmentNo>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001459839</issuerCik>
        <issuerName>SI-BONE, Inc.</issuerName>
        <issuerCusip>825704109</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <ns1:street1>471 El Camino Real</ns1:street1>
          <ns1:street2>Suite 101</ns1:street2>
          <ns1:city>Santa Clara</ns1:city>
          <ns1:stateOrCountry>CA</ns1:stateOrCountry>
          <ns1:zipCode>95050</ns1:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>BROWN ADVISORY INC</reportingPersonName>
      <citizenshipOrOrganization>MD</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>2669868</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>3219079</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3219079</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>7.6</classPercent>
      <typeOfReportingPerson>HC</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>BROWN INVESTMENT ADVISORY &amp; TRUST CO</reportingPersonName>
      <citizenshipOrOrganization>MD</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>18203</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>18203</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>18203</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>0</classPercent>
      <typeOfReportingPerson>BK</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>BROWN ADVISORY LLC</reportingPersonName>
      <citizenshipOrOrganization>MD</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>2650771</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>3198548</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3198548</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>7.5</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>SIGNATURE FINANCIAL MANAGEMENT, INC.</reportingPersonName>
      <citizenshipOrOrganization>VA</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>894</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>2328</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2328</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>0</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>SI-BONE, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>471 El Camino Real
Suite 101
Santa Clara, CALIFORNIA
95050</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>BROWN ADVISORY INC

BROWN INVESTMENT ADVISORY &amp; TRUST CO

BROWN ADVISORY LLC

SIGNATURE FINANCIAL MANAGEMENT, INC.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>901 SOUTH BOND STREET
SUITE #400
Baltimore, Maryland
21231</principalBusinessOfficeOrResidenceAddress>
        <citizenship>BROWN ADVISORY INC - MARYLAND

BROWN INVESTMENT ADVISORY &amp; TRUST CO - MARYLAND

BROWN ADVISORY LLC - MARYLAND

SIGNATURE FINANCIAL MANAGEMENT, INC. - VIRGINIA</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>BK</typeOfPersonFiling>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
        <typeOfPersonFiling>HC</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>3,219,079</amountBeneficiallyOwned>
        <classPercent>7.6</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>BROWN ADVISORY INC - 2,669,868

BROWN INVESTMENT ADVISORY &amp; TRUST CO - 18,203

BROWN ADVISORY LLC - 2,650,771

SIGNATURE FINANCIAL MANAGEMENT, INC. - 894</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>BROWN ADVISORY INC - 0

BROWN INVESTMENT ADVISORY &amp; TRUST CO - 0

BROWN ADVISORY LLC - 0

SIGNATURE FINANCIAL MANAGEMENT, INC. - 0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>BROWN ADVISORY INC - 0

BROWN INVESTMENT ADVISORY &amp; TRUST CO - 0

BROWN ADVISORY LLC - 0

SIGNATURE FINANCIAL MANAGEMENT, INC. - 0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>BROWN ADVISORY INC - 3,219,079

BROWN INVESTMENT ADVISORY &amp; TRUST CO - 18,203

BROWN ADVISORY LLC - 3,198,548

SIGNATURE FINANCIAL MANAGEMENT, INC. - 2,328</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>N</notApplicableFlag>
        <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>The total securities being reported are beneficially owned by investment companies and other managed accounts of direct/indirect subsidiaries of BROWN ADVISORY INC (listed above). These subsidiaries may be deemed to be beneficial owners of the reported securities because applicable investment advisory contracts provide voting and/or investment power over securities.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
      </item6>
      <item7>
        <notApplicableFlag>N</notApplicableFlag>
        <subsidiaryIdentificationAndClassification>BROWN ADVISORY INC is a parent holding company filing this schedule on behalf of the following subsidiaries pursuant to Rule 13d-1(b)(1)(ii)(G) under the Securities Exchange Act of 1934:
BROWN INVESTMENT ADVISORY &amp; TRUST CO - BK (Bank)
BROWN ADVISORY LLC - IA (Investment Adviser)
SIGNATURE FINANCIAL MANAGEMENT, INC. - IA (Investment Adviser)</subsidiaryIdentificationAndClassification>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>BROWN ADVISORY INC</reportingPersonName>
      <signatureDetails>
        <signature>Brett D. Rogers</signature>
        <title>General Counsel &amp; Chief Compliance Officer</title>
        <date>04/18/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>BROWN INVESTMENT ADVISORY &amp; TRUST CO</reportingPersonName>
      <signatureDetails>
        <signature>Brett D. Rogers</signature>
        <title>General Counsel &amp; Chief Compliance Officer</title>
        <date>04/18/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>BROWN ADVISORY LLC</reportingPersonName>
      <signatureDetails>
        <signature>Brett D. Rogers</signature>
        <title>General Counsel &amp; Chief Compliance Officer</title>
        <date>04/18/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>SIGNATURE FINANCIAL MANAGEMENT, INC.</reportingPersonName>
      <signatureDetails>
        <signature>Brett D. Rogers</signature>
        <title>General Counsel &amp; Chief Compliance Officer</title>
        <date>04/18/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
