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Summary of Significant Accounting Policies - Share-based Compensation by Award Type - Additional Information (Detail) - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2005
Employee Stock Purchase Plan [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term 6 months 6 months 6 months  
Expected volatility 87.00% 61.00% 80.00%  
Risk-free interest rate 0.19% 0.86% 0.70%  
Dividend yield 0.00% 0.00% 0.00%  
Unrecognized compensation costs related to non-vested stock option awards $ 1,725,000      
Costs expected to be recognized over a weighted average period       3 years
Restricted Stock Units [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term     10 years  
Expected volatility     99.40%  
Risk-free interest rate     1.94%  
Dividend yield     0.00%  
Employee Stock Option [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term 5 years 5 years 5 years  
Expected volatility 86.00% 83.00% 99.00%  
Risk-free interest rate 1.60% 1.66% 0.86%  
Dividend yield 0.00% 0.00% 0.00%  
Unrecognized compensation costs $ 94,000      
Costs expected to be recognized over a weighted average period       1 year 1 month 6 days
Restricted stock unit awards [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Unrecognized compensation costs $ 3,000      
Costs expected to be recognized over a weighted average period       6 months