Consolidated Statements of Loss and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue
Collaboration revenue	$ 2,671	$ 2,997	$ 46,965
Product sales	2,355	2,564	874
Total revenues	5,026	5,561	47,839
Cost of goods sold	21,129	15,925	11,209
Research and development	11,716	13,748	19,082
General and administrative	12,205	13,344	15,778
Total operating expenses	45,050	43,017	46,069
Loss from operations	(40,024)	(37,456)	1,770
Change in fair value of contingent consideration liability	27,132	8,149	(39,913)
Interest and other income/expense, net	28	13	26
Interest expense	(8,446)	(7,438)	(1,498)
Net loss	(21,310)	(36,732)	(39,615)
Change in unrealized (loss) income on marketable securities	3	(4)	1
Comprehensive loss	$ (21,307)	$ (36,736)	$ (39,614)
Net loss per share - basic and diluted	$ (1.08)	$ (2.07)	$ (2.38)
Shares used to compute net loss per share - basic and diluted	19,810	17,784	16,669