<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001344413</cik>
        <entityName>Alexza Pharmaceuticals Inc.</entityName>
        <issuerAddress>
            <street1>2091 STIERLIN COURT</street1>
            <city>MOUNTAIN VIEW</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>94043</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>650.944.7000</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>B</middleName>
                <lastName>King</lastName>
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            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>V</middleName>
                <lastName>Cassella</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>August</firstName>
                <middleName>J</middleName>
                <lastName>Moretti</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>J</middleName>
                <lastName>Simms</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Hal</firstName>
                <middleName>V</middleName>
                <lastName>Barron</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Samuel</firstName>
                <middleName>D</middleName>
                <lastName>Colella</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alan</firstName>
                <middleName>D</middleName>
                <lastName>Frazier</lastName>
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            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Deepika</firstName>
                <middleName>R</middleName>
                <lastName>Pakianathan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>J</firstName>
                <middleName>Leighton</middleName>
                <lastName>Read</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gordon</firstName>
                <lastName>Ringold</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Isaac</firstName>
                <lastName>Stein</lastName>
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                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
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            <relatedPersonRelationshipList>
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            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andrew</firstName>
                <middleName>L</middleName>
                <lastName>Busser</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2091 Stierlin Court</street1>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94043</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-10-05</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>RBC Capital Markets Corporation</recipientName>
                <recipientCRDNumber>31194</recipientCRDNumber>
                <associatedBDName>RBC Capital Markets Corporation</associatedBDName>
                <associatedBDCRDNumber>31194</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>2 Embarcadero Center, Ste 1200</street1>
                    <city>San Francisco</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>94111</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CT</state>
                    <state>IL</state>
                    <state>MD</state>
                    <state>MA</state>
                    <state>MN</state>
                    <state>NJ</state>
                    <state>NY</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>19720309</totalOfferingAmount>
            <totalAmountSold>19720309</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>30</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>551028</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Alexza Pharmaceuticals Inc.</issuerName>
                <signatureName>/s/ Thomas B. King</signatureName>
                <nameOfSigner>Thomas B King</nameOfSigner>
                <signatureTitle>President &amp; Chief Executive Officer</signatureTitle>
                <signatureDate>2009-10-06</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
