X0306 4 2016-06-21 1 0001344413 Alexza Pharmaceuticals Inc. ALXA 0001209726 BUCHI J KEVIN C/O ALEXZA PHARMACEUTICALS INC. 2091 STIERLIN COURT MOUNTAIN VIEW CA 94043 1 0 0 0 Stock Option (right to buy) 1.28 2016-06-21 4 D 0 12500 0.00 D 2016-06-03 2025-06-22 Common Stock 12500 0 D Stock Option (right to buy) 4.35 2016-06-21 4 D 0 12500 0.00 D 2015-06-10 2024-06-09 Common Stock 12500 0 D Stock Option (right to buy) 5.13 2016-06-21 4 D 0 20000 0.00 D 2013-02-02 2023-01-01 Common Stock 20000 0 D Disposed of pursuant to Section 3.4(a) of the Agreement and Plan of Merger, dated 5/9/16, among the Issuer, Grupo Ferrer Internactional, S.A. and Ferrer Pharma Inc. (the "Agreement), whereby each option that was outstanding immediately prior to the Offer Closing (as defined in the Agreement) was cancelled without consideration. /s/ Brent D. Fassett, as Attorney-in-Fact for J. Kevin Buchi 2016-06-21