X0306 4 2015-04-30 0 0001344413 Alexza Pharmaceuticals Inc. ALXA 0001279309 KING THOMAS BRAXTON C/O ALEXZA PHARMACEUTICALS, INC. 2091 STIERLIN COURT MOUNTAIN VIEW CA 94043 1 1 0 0 President and CEO Common Stock 35223 I By The Thomas and Beth King 2000 Family Trust, as co-trustee Common Stock 40000 D Includes 1,576 shares acquired under the Alexza Pharmaceuticals, Inc. 2005 Employee Stock Purchase Plan on April 30, 2015. /s/ Brent D. Fassett, Attorney-in Fact 2015-05-04