X0303 4 2009-05-07 0001344413 Alexza Pharmaceuticals Inc. ALXA 0001201580 COLELLA SAMUEL D VERSANT VENTURES 3000 SAND HILL ROAD, BLDG FOUR, STE 210 MENLO PARK CA 94025 1 0 0 0 Stock Option (right to buy) 1.69 2009-05-07 4 A 0 6250 0 A 2009-06-07 2019-05-07 Common Stock 6250 6250 D Automatic grant to Reporting Person of a non-statutory stock option. 1/48th of the shares vest monthly from the date of grant over four years. The option expires ten years after the date of grant, unless it expires sooner pursuant to the terms of the Company's 2005 Non-Employee Directors' Stock Option Plan. /s/ Brent D. Fassett, Attorney-in-Fact 2009-05-11