Commitments - Operating Leases - Additional Information (Detail) (USD $)	12 Months Ended			1 Months Ended	0 Months Ended	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Aug. 31, 2010 Agreement to sublease [Member] Cypress Bioscience, Inc. [Member] sqft	Mar. 30, 2012 2023 Building [Member] sqft	Dec. 31, 2013 2091 Building [Member] Option
Operating Leased Assets [Line Items]
Expiry of lease of 2091 Building						Mar. 31, 2018
Operating leases renewal term, duration						5 years
Operating leases options						2
Area of building subleased				2,500
Description of sublease terms				To provide certain administrative, facility and information technology support for a period of 12 months and on a month-to-month basis thereafter
Termination of 2023 lease Building, square feet					41,290
General and administrative expenses	$ 15,778,000	$ 11,093,000	$ 11,766,000		$ 1,421,000
Deferred rent liability					2,073,000
Depreciation	3,323,000	4,336,000	4,432,000		652,000
Rent expenses, net of sublease income	2,286,000	1,972,000	2,000,000
Rental income from the sublease agreement	$ 0	$ 340,000	$ 1,584,000