Consolidated Statements of Loss and Comprehensive Loss (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Income Statement [Abstract]
Revenue	$ 47,839	$ 4,070	$ 5,660
Operating expenses:
Cost of goods sold	11,209
Research and development	19,082	21,849	28,262
General and administrative	15,778	11,093	11,766
Total operating expenses	46,069	32,942	40,028
Income (loss) from operations	1,770	(28,872)	(34,368)
(Loss) gain on change in fair value of contingent consideration liability	(39,913)	1,900	(4,000)
Interest and other income/expense, net	26	420	26
Interest expense	(1,498)	(1,426)	(2,189)
Net loss	(39,615)	(27,978)	(40,531)
Basic and diluted net loss per share	$ (2.38)	$ (2.24)	$ (5.97)
Shares used to compute basic and diluted net loss per share	16,669	12,472	6,787
Other Comprehensive Loss:
Change in unrealized (loss)/gain on marketable securities	1		(2)
Comprehensive loss	$ (39,614)	$ (27,978)	$ (40,533)