X0306 4 2015-07-22 0 0001344413 Alexza Pharmaceuticals Inc. ALXA 0001491847 Oki Mark K ALEXZA PHARMACEUTICALS, INC. 2091 STIERLIN COURT MOUNTAIN VIEW CA 94043 0 1 0 0 SVP, Finance, CFO & Sec Stock Option (right to buy) 1.08 2015-07-22 4 A 0 125000 0.00 A 2025-07-21 Common Stock 125000 125000 D Grant to the Reporting Person of a stock option under the Issuer's 2015 Equity Incentive Plan (the "Plan"). The shares vest in 48 equal monthly installments commencing on August 21, 2015, provided, that in each case, the Reporting Person's continuous service to the Issuer has not been terminated as defined in or as determined under the Plan, and provided further, that in the event that the Company terminates the Reporting Person's employment as of or within three (3) months prior to or twelve (12) months following a Change in Control (as defined in the Plan), then the option shall become fully vested and immediately exercisable as of such date. The option expires ten years after the date of grant. /s/ Brent D. Fassett, Attorney-in-Fact 2015-07-24