X0306 4 2022-12-30 0 0001492426 Horizon Therapeutics Public Ltd Co HZNP 0001342821 Himawan Jeff C/O HORIZON THERAPEUTICS PLC, 70 ST. STEPHEN?S GREEN DUBLIN L2 D02 E2X4 IRELAND 1 0 0 0 Ordinary Shares 2022-12-30 5 G 0 E 2230 0.00 D 7960 D Ordinary Shares 46873 I By Trust Reflects transfer of 10,190 ordinary shares from Trust to direct holdings. /s/ Meghanne Downes, Attorney-in-Fact 2023-01-04