X0306 4 2015-03-12 0 0001492426 Horizon Pharma plc HZNP 0001342821 Himawan Jeff 21 WATERWAY AVENUE, SUITE 225 THE WOODLANDS TX 77380 1 0 0 0 Common Stock 2015-03-12 4 X 0 690369 4.308 A 690369 I See Foot note Common Stock 2015-03-12 4 D 0 135805 4.038 D 554564 I See Foot note Common Stock 2015-03-12 4 S 0 197277 22.59 D 357287 I See Foot note Common Stock 2015-03-13 4 S 0 357287 22.35 D 0 I See Foot note Warrant 4.308 2015-03-12 4 X 0 690369 0.00 D 2012-03-02 2017-03-02 Common Stock 690369 690369 I See Foot note Represents shares underlying warrants. Essex Woodlands Health Ventures Fund, VII, L.P. (the "Fund") exercised warrants for 690,369 shares. Shares received by the Fund are net of shares withheld, as described in footnote (3), due to net exercise of warrants. The securities are held directly by the Fund. The Reporting Person is a manager of Essex Woodlands Health Ventures VII, L.L.C., which is the general partner of Essex Woodlands Health Ventures VII, L.P., the general partner of the Fund. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein. Represents 135,805 shares withheld in connection with the net exercise of warrants. Such shares are held by the issuer in satisfaction of the warrant's exercise price and did not involve any sale of shares by the Fund. Price Range of $22.41 to $22.90. Price Range of $22.20 to $22.62. /s/ Richard Kolodziejcyk, Attorney-in-Fact 2015-03-16