X0306 4 2015-03-09 0 0001492426 Horizon Pharma plc HZNP 0001342821 Himawan Jeff 21 WATERWAY AVENUE, SUITE 225 THE WOODLANDS TX 77380 1 0 0 0 Ordinary Shares 2015-03-09 4 S 0 329912 21.91 D 1284915 I See footnote Ordinary Shares 2015-03-10 4 S 0 1284915 21.84 D 0 I See footnote The securities are held directly by Essex Woodlands Health Ventures Fund, VII, L.P. (the "Fund"). The Reporting Person is a manager of Essex Woodlands Health Ventures VII, L.L.C., which is the general partner of Essex Woodlands Health Ventures VII, L.P., the general partner of the Fund. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein. /s/ Richard Kolodziejcyk, Attorney-in-Fact 2015-03-11