X0202 4 2006-11-12 0001226616 MEDICINOVA INC 4875 OSE 0001342821 Himawan Jeff 4350 LA JOLLA VILLAGE DRIVE, SUITE 950 SAN DIEGO CA 92122 1 0 0 0 Stock Option (right to buy) 9.73 2006-11-12 4 A 0 20000 0 A 2016-11-11 Common Stock 20000 20000 I By Essex Woodlands Health Ventures Fund VI, L.P. The option is fully vested and exercisable on November 12, 2007. The Reporting Person is a managing member of Essex Woodlands Health Ventures VI, LLC and is a limited partner of Essex Woodlands Health Ventures VI, L.P. Essex Woodlands Health Ventures VI, LLC is the general partner of Essex Woodlands Health Ventures VI, L.P., which is the general partner of Essex Woodlands Health Ventures Fund VI, L.P. Pursuant to Instruction (4)(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by such entities. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his pecuniary interest therein and/or that are not actually distributed to him. /s/ Shintaro Asako, Attorney-in-Fact 2006-11-14