X0202 4 2006-01-09 0001226616 MEDICINOVA INC 4875 OSE 0001342821 Himawan Jeff 4350 LA JOLLA VILLAGE DR., SUITE 950 SAN DIEGO, CA 92122 1 0 0 0 Stock Option (right to buy) 1.48 2006-01-09 4 A 0 100000 0 A 2006-01-09 2016-01-08 Common Stock 100000 100000 I By Essex Woodlands Health Ventures, Inc. Stock Option (right to buy) 1.48 2006-01-09 4 A 0 100000 0 A 2016-01-08 Common Stock 100000 100000 I By Essex Woodlands Health Ventures, Inc. Stock Option (right to buy) 1.48 2006-01-09 4 A 0 10000 0 A 2006-01-09 2016-01-08 Common Stock 10000 10000 I By Essex Woodlands Health Ventures, Inc. The exercise price of this stock option is 170 yen. On the date of grant, the exercise price was equal to $1.48, based on the exchange rate as found on www.oanda.com. The Reporting Person is a managing member of Essex Woodlands Health Ventures VI, L.L.C. and is a limited partner of Essex Woodlands Health Ventures VI, L.P. Essex Woodlands Health Ventures VI, L.L.C. is the general partner of Essex Woodlands Health Ventures VI, L.P., which is the general partner of Essex Woodlands Health Ventures Fund VI, L.P. Essex Woodlands Health Ventures, Inc. is the management company for Essex Woodlands Health Ventures Fund VI, L.P. Pursuant to Instruction (4)(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by such entities. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his pecuniary interest therein and/or that are not actually distributed to him. The option vests over a four (4) year period commencing January 9, 2006, in equal quarterly installments. /s/ Shintaro Asako, as Attorney-in-Fact 2006-06-20