X0202 4 2008-02-12 0 0001178879 AMICUS THERAPEUTICS INC FOLD 0001341382 Topper James N 550 HAMILTON AVENUE, SUITE 100 PALO ALTO CA 94301 1 0 1 0 Common Stock 2008-02-13 4 P 0 800 10.44 A 624667 I By Frazier Healthcare V, LP Common Stock 2008-02-13 4 P 0 300 10.45 A 624967 I By Frazier Healthcare V, LP Common Stock 2008-02-13 4 P 0 600 10.46 A 625567 I By Frazier Healthcare V, LP Common Stock 2008-02-13 4 P 0 100 10.47 A 625667 I By Frazier Healthcare V, LP Common Stock 2008-02-13 4 P 0 100 10.48 A 625767 I By Frazier Healthcare V, LP Common Stock 2008-02-13 4 P 0 900 10.49 A 626667 I By Frazier Healthcare V, LP Common Stock 2008-02-13 4 P 0 3000 10.50 A 629667 I By Frazier Healthcare V, LP Common Stock 2586886 I By Frazier Healthcare IV, LP Common Stock 13128 I By Frazier Affiliates IV, LP The securities are owned directly by the entity listed. Dr. Topper is a member of the investment committee of FHM V, LLC, the general partner of FHM V, L.P., which is the general partner of Frazier Healthcare V, L.P. As a member of the FHM V, LLC investment committee, Dr. Topper may be deemed to share voting and investment power for securities held by Frazier Healthcare V, L.P. Dr. Topper disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of Section 16 or for any other purpose. There is no direct relationship among or between FHM V, LLC, FHM V, L.P. and Frazier Healthcare V, L.P., on the one hand, and FHM IV, LP, Frazier Healthcare IV, LP and Frazier Affiliates IV, LP, on the other. Beneficial ownership of Issuer shares as described herein and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of Section 16 or for any other purpose. The securities are owned directly by the entity listed. Dr. Topper is a limited partner of FHM IV, LP, the general partner of Frazier Healthcare IV, LP and Frazier Affiliates IV, LP. Voting and investment power over such shares is exercised by FHM IV, LLC in its role as the general partner of FHM IV, LP. Dr. Topper is not a member or an officer of FHM IV, LLC. Dr. Topper disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of Section 16 or for any other purpose. /s/ James Topper 2008-02-14