X0202 4 2008-02-12 0 0001178879 AMICUS THERAPEUTICS INC FOLD 0001341382 Topper James N 550 HAMILTON AVENUE, SUITE 100 PALO ALTO CA 94301 1 0 1 0 Common Stock 2008-02-12 4 P 0 709 9.99 A 608976 I By Frazier Healthcare, V, LP Common Stock 2008-02-12 4 P 0 1200 10.00 A 610176 I By Frazier Healthcare, V, LP Common Stock 2008-02-12 4 P 0 2000 10.01 A 612176 I By Frazier Healthcare, V, LP Common Stock 2008-02-12 4 P 0 1891 10.02 A 614067 I By Frazier Healthcare, V, LP Common Stock 2008-02-12 4 P 0 1600 10.03 A 615667 I By Frazier Healthcare, V, LP Common Stock 2008-02-12 4 P 0 600 10.04 A 616267 I By Frazier Healthcare, V, LP Common Stock 2008-02-12 4 P 0 800 10.05 A 617067 I By Frazier Healthcare, V, LP Common Stock 2008-02-12 4 P 0 300 10.06 A 617367 I By Frazier Healthcare, V, LP Common Stock 2008-02-12 4 P 0 200 10.10 A 617567 I By Frazier Healthcare, V, LP Common Stock 2008-02-12 4 P 0 100 10.12 A 617667 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 101 10.10 A 617768 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 100 10.17 A 617868 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 200 10.18 A 618068 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 200 10.20 A 618268 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 100 10.21 A 618368 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 200 10.24 A 618568 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 292 10.25 A 618860 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 707 10.26 A 619567 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 100 10.30 A 619667 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 100 10.32 A 619767 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 200 10.33 A 619967 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 600 10.34 A 620567 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 500 10.35 A 621067 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 600 10.37 A 621667 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 1000 10.38 A 622667 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 400 10.39 A 623067 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 200 10.40 A 623267 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 300 10.41 A 623567 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 100 10.42 A 623667 I By Frazier Healthcare, V, LP Common Stock 2008-02-13 4 P 0 200 10.43 A 623867 I By Frazier Healthcare, V, LP The securities are owned directly by the entity listed. Dr. Topper is a member of the investment committee of FHM V, LLC, the general partner of FHM V, L.P., which is the general partner of Frazier Healthcare V, L.P. As a member of the FHM V, LLC investment committee, Dr. Topper may be deemed to share voting and investment power for securities held by Frazier Healthcare V, L.P. Dr. Topper disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of Section 16 or for any other purpose. There is no direct relationship among or between FHM V, LLC, FHM V, L.P. and Frazier Healthcare V, L.P., on the one hand, and FHM IV, LP, Frazier Healthcare IV, LP and Frazier Affiliates IV, LP, on the other. Beneficial ownership of Issuer shares as described herein and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of Section 16 or for any other purpose. /s/ James N. Topper 2008-02-14