The SOLACE Trial in Noninfectious Anterior Uveitis Top-Line Results Nasdaq: ALDX ©Aldeyra Therapeutics, Inc. 2019 June 2019 Exhibit 99.1

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No statistically significant difference was observed between the reproxalap group and the vehicle control group on the primary (time to cure) or secondary endpoints, due to high rates of disease resolution in vehicle-treated patients. For the primary and all time-to-event secondary endpoints, reproxalap was numerically favored over vehicle. The ocular inflammation improvement in the reproxalap group was consistent with Phase 2 trial results, which were statistically noninferior to corticosteroid therapy. Reproxalap activity in reducing ocular inflammation in patients with moderate disease, a pre-specified subgroup, was statistically superior to that of vehicle. Topical ocular reproxalap was observed to be safe and well tolerated, consistent with prior clinical trials. Aldeyra intends to discontinue the noninfectious anterior uveitis program in order to prioritize high-value Phase 3 ocular programs in dry eye disease, allergic conjunctivitis, and proliferative vitreoretinopathy. Top-Line SOLACE Trial Results Summary

The SOLACE Trial Design Primary objective Evaluate efficacy of reproxalap ophthalmic solution (0.5%) on anterior chamber cell count (ACC) vs. vehicle Inclusion highlights Acute endogenous noninfectious anterior uveitis with onset of symptoms within the previous 2 weeks 6-50 ACC in the study eye Intraocular pressure <21 mmHg Dosing regimen Week 1 8x/day Week 2 6x/day Weeks 3-4 4x/day Week 5None Endpoints Primary Endpoint: Time-to-cure (zero inflammatory cells in anterior chamber) without rescue Secondary Time-to-Event Endpoints: one-point ACC grade reduction, flare cure, one-point flare grade reduction, requirement for rescue therapy Day 1 (Screening) Day 4 Day 15 Day 22 Day 36 Day 8 Day 29 Reproxalap 0.5% (N = 61) Vehicle (N = 62) Treatment Further information can be found on www.clinicaltrials.gov: Trial #NCT03131154.

Primary and Secondary Time to Event Endpoints – Overall Population Endpoint Reproxalap Vehicle p value Time to Cure (Anterior Cell Grade 0) 15 days 21 days NS Time to Anterior Cell Grade 1-Point Improvement 7 days 8 days NS Time to Flare Grade 0 8 days 15 days NS Time to Flare Grade 1-Point Improvement 5 days 6 days NS Time to Rescue Therapy 15 days 12 days NS Time to event represents 25th percentile Kaplan Meier estimates. Time to event p values represent log-rank tests. Source: SOLACE noninfectious anterior uveitis clinical trial results NS = Not Significant

ITT = Intention-To-Treat Source: SOLACE noninfectious anterior uveitis clinical trial results and Phase 2 noninfectious anterior uveitis clinical trial results Immune-Modulating Activity Observed in SOLACE Consistent with Phase 2 Trial Results, Which Were Statistically Noninferior to Corticosteroid Mean Change from Baseline Day 4 Day 7 Day 14 Day 28 Day 4 Day 8 Day 15 Day 22 Day 29 Change from Baseline in Anterior Chamber Inflammatory Cell Grade ITT Population with Last Observation Carried Forward Phase 2 SOLACE

Moderate patients defined as patients with anterior chamber cell count grade of 2+. Time to event represents 25th percentile Kaplan Meier estimates. Time to event p values represent log-rank tests. The combined p value is the fixed effect meta-analysis of log hazard ratios. Source: SOLACE noninfectious anterior uveitis clinical trial results Primary and Secondary Time to Event Endpoints – Moderate Patients (a Pre-Specified Subgroup) Endpoint Reproxalap Vehicle p value Time to Cure (Anterior Cell Grade 0) 15 days 31 days 0.08 Time to Anterior Cell Grade 1-Point Improvement 4 days 6 days 0.1 Time to Flare Grade 0 5 days > 32 days 0.03 Time to Flare Grade 1-Point Improvement 5 days 20 days 0.1 Time to Rescue Therapy 15 days 7 days 0.06 Combined 0.0001

Immune-Modulating Activity of Reproxalap was Statistically Superior to that of Vehicle in Patients with Moderate Severity (a Pre-Specified Subgroup) Proportion Cured (Grade 0 = no inflammatory cells observed) Week 4 Grade 0 Percent of Subjects Reproxalap 53% Vehicle 25% Mean Change from Baseline Day 4 Day 8 Day 15 Day 22 Change from Baseline in Anterior Chamber Inflammatory Cell Grade Moderate Severity ITT Population with Last Observation Carried Forward Day 29 MMRM p = 0.0489 Moderate severity defined as patients with anterior chamber cell count grade of 2+. Source: SOLACE noninfectious anterior uveitis clinical trial results *p<0.05 MMRM = Mixed Effect Model Repeated Measures * * *

Now administered to over 800 patients across nine completed clinical trials No observed safety or tolerability concerns, consistent with previous clinical trials Topical Ocular Reproxalap Was Generally Well Tolerated and No Safety Concerns Were Observed in SOLACE Source: SOLACE noninfectious anterior uveitis clinical trial results Change from Baseline in Intraocular Pressure (mmHg) Safety Population Mean Change from Baseline Day 4 Day 7 Day 14 Day 22 Day 29

Aldeyra intends to prioritize high-value Phase 3 ocular programs Ocular Program Status Allergic Conjunctivitis Positive ALLEVIATE Phase 3 clinical trial results, announced March 2019 Positive allergen chamber clinical trial results, announced June 2019 Subsequent Phase 3 trial expected to be confirmed H2 2019 Dry Eye Disease Positive Phase 2b clinical trial results, announced September 2018 RENEW Phase 3 clinical trial program ongoing Proliferative Vitreoretinopathy Phase 3 clinical program initiation expected H2 2019