Income Taxes - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Income Tax Contingency [Line Items]
Current provision for income tax benefit	$ 0	$ (479,265)
Deferred tax assets valuation allowance	100.00%
Net operating loss carryforwards expire period	2041
Increasing in research activities expire period	2041
Statutory tax rate	21.00%	21.00%
Change in valuation allowance	$ 18,100,000
Federal orphan drug tax credit carryforward	$ 1,000,000.0
Maximum [Member]
Income Tax Contingency [Line Items]
Statutory tax rate	50.00%
State and Federal [Member]
Income Tax Contingency [Line Items]
Current provision for income tax benefit	$ 0
Federal [Member]
Income Tax Contingency [Line Items]
Net operating loss carryforwards	226,000,000.0
Increasing in research activities	6,900,000
State [Member]
Income Tax Contingency [Line Items]
Net operating loss carryforwards	219,000,000.0
Increasing in research activities	$ 1,600,000