X0202 4 2006-08-16 0 0001027702 EPIX Pharmaceuticals, Inc. EPIX 0001340887 Becker Oren M C/O EPIX PHARMACEUTICALS, INC. 4 MAGUIRE ROAD LEXINGTON MA 02421 0 1 0 0 Chief Scientific Officer Common Stock 2006-08-16 4 A 0 3684 A 3684 D Stock Option (Right to Buy) 2.18 2006-08-16 4 A 0 10527 A 2013-08-11 Common Stock 10527 10527 D Stock Option (Right to Buy) 2.18 2006-08-16 4 A 0 5045 A 2013-08-11 Common Stock 5045 5045 D Stock Option (Right to Buy) 2.18 2006-08-16 4 A 0 1836 A 2014-04-29 Common Stock 1836 1836 D Stock Option (Right to Buy) 0.98 2006-08-16 4 A 0 95698 A 2014-09-23 Common Stock 95698 95698 D Stock Option (Right to Buy) 0.98 2006-08-16 4 A 0 22456 A 2014-09-23 Common Stock 22456 22456 D Stock Option (Right to Buy) 0.98 2006-08-16 4 A 0 69549 A 2015-01-18 Common Stock 69549 69549 D Stock Option (Right to Buy) 1.74 2006-08-16 4 A 0 10948 A 2015-04-28 Common Stock 10948 10948 D Received in exchange for 4,457 shares of Predix Pharmaceuticals Holdings, Inc. ("Predix") common stock based on an exchange ratio of 0.826702 in connection with the merger of EPIX Pharmaceuticals, Inc. ("EPIX") and Predix (the "Merger") and after EPIX having effected a 1 for 1.5 reverse stock split. On the effective date of the Merger, the closing price of EPIX?s common stock was $4.85 per share. Received in the Merger in exchange for a stock option to acquire 12,735 shares of Predix common stock for $1.80 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option vests over a four year period at a rate of 25% on July 31, 2004, and the balance vesting in equal annual installments over the remaining three years. Received in the Merger in exchange for a stock option to acquire 6,104 shares of Predix common stock for $1.80 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option vested in full on August 8, 2003. Received in the Merger in exchange for a stock option to acquire 2,222 shares of Predix common stock for $1.80 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option began vesting in 16 quarterly installments of 6.25% each on July 29, 2004. Received in the Merger in exchange for a stock option to acquire 115,764 shares of Predix common stock for $0.81 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option vested in full on November 1, 2004. Received in the Merger in exchange for a stock option to acquire 27,165 shares of Predix common stock for $0.81 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option vested in full on November 1, 2004. Received in the Merger in exchange for a stock option to acquire 84,133 shares of Predix common stock for $0.81 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option began vesting in 48 approximately equal monthly installments on February 18, 2005. Received in the Merger in exchange for a stock option to acquire 13,244 shares of Predix common stock for $1.44 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option began vesting in 48 approximately equal monthly installments on August 1, 2005. /s/ Michael Berdik Attorney-in-Fact 2006-08-18