X0202 4/A 2006-12-20 2006-12-21 0 0001340744 Altus Pharmaceuticals Inc. ALTU 0001350093 Gallotto Robert C/O ALTUS PHARMACEUTICALS INC. 125 SIDNEY STREET CAMBRIDGE MA 02139 0 1 0 0 VP, Strategic Planning Common Stock 2006-12-20 4 M 0 7000 3.92 A 7000 D Common Stock 2006-12-20 4 S 0 7000 20.00 D 0 D Common Stock Option (Right to buy) 3.92 2006-12-20 4 M 0 5892 0.00 D 2001-12-21 2011-12-20 Common Stock 5892 1594 D Common Stock Option (Right to buy) 3.92 2006-12-20 4 M 0 1108 0.00 D 2002-12-20 2012-12-19 Common Stock 1108 40322 D The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by Mr. Gallotto on September 1, 2006. All of such options have a term of ten years vesting over four years, with 1/16 of the options vesting every three months. /s/ Robert Gallotto 2007-01-04