X0306 4 2021-05-20 0 0001340652 ChemoCentryx, Inc. CCXI 0001324991 Tyree James L C/O CHEMOCENTRYX, INC. 835 INDUSTRIAL ROAD, SUITE 600 SAN CARLOS CA 94070 1 0 0 0 Common Stock 2021-05-21 4 M 0 4660 0.00 A 17729 D Common Stock 2021-05-21 4 S 0 2454 9.762 D 15275 D Restricted Stock Units 2021-05-20 4 A 0 7726 A Common Stock 7726 7726 D Stock Option (right to buy) 10.06 2021-05-20 4 A 0 4504 A 2022-05-20 2031-05-20 Common Stock 4504 4504 D Restricted Stock Units 2021-05-21 4 M 0 4660 D Common Stock 4660 0 D Shares were acquired upon vesting of restricted stock units awarded on May 21, 2020. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person to cover anticipated taxes due upon vesting of restricted stock unit shares. Reflects the weighted average sale price of the shares sold. The shares were sold in multiple trades at prices ranging from $9.65 to $10.03 per share. The Reporting Person will provide to the SEC staff, the issuer or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price. Each restricted stock unit represents a contingent right to receive one share of CCXI common stock. The restricted stock units awarded on May 20, 2021, vests on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Company on such date. Shares will be delivered to the Reporting Person within thirty (30) days following vest date. The option granted on May 20, 2021, vests on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Company on such date. Not applicable. 100% of the restricted stock units vested on May 21, 2021. Vested shares will be delivered to the Reporting Person within thirty (30) days following vest date. /s/ Susan M. Kanaya, as Attorney-in-Fact 2021-05-24