Income Taxes - Tax Effects of Temporary Differences and Carryforwards that Give Rise to Significant Portions of the Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Net operating loss carryforwards	$ 143,914	$ 120,347
Tax credits	54,585	49,229
Stock based compensation	5,485	4,165
Reserves and accruals	3,034	1,770
Deferred revenue	7,657	7,684
Lease liability	10,628	8,299
Gross deferred tax assets	225,303	191,494
Less: valuation allowance	(216,025)	(183,948)
Total deferred tax assets	9,278	7,546
Deferred tax liabilities:
Property, plant and equipment	(3,967)	(1,894)
Right of use asset	5,311	5,652
Total deferred tax liabilities	(9,278)	(7,546)
Net deferred tax assets	$ 0	$ 0

Deferred tax assets lease liability.

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Deferred tax liability right of use assets.

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Amount, after deferred tax asset, of deferred tax liability attributable to taxable differences with jurisdictional netting.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from deferred income.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards.

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Amount, before allocation of a valuation allowances, of deferred tax assets attributable to deductible tax credit carryforwards including, but not limited to, research, foreign, general business, alternative minimum tax, and other deductible tax credit carryforwards.

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Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences from reserves, classified as other.

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Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.

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Amount of deferred tax liability attributable to taxable temporary differences from property, plant, and equipment.

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