Balance Sheet Details - Summary of Prepaid Expenses (Detail) - USD ($) $ in Thousands		Dec. 31, 2021	Dec. 31, 2020
Prepaid Expenses [Line Items]
Prepaid expenses		$ 5,223	$ 1,803
Prepaid Clinical and Research Expense [Member]
Prepaid Expenses [Line Items]
Prepaid expenses		557	583
Prepaid Manufacturing Expenses [Member]
Prepaid Expenses [Line Items]
Prepaid expenses	[1]	4,188	513
Other Prepaid Expenses [Member]
Prepaid Expenses [Line Items]
Prepaid expenses		$ 478	$ 707

[1] Prepaid manufacturing expenses of $3.7 million incurred in 2021 included a reservation fee and raw materials for manufacturing of efzofitimod clinical trial materials planned to occur in the second half of 2022