X0407 4 2023-05-17 0 0001339970 aTYR PHARMA INC LIFE 0001219015 CLARKE JOHN K C/O ATYR PHARMA, INC. 10240 SORRENTO VALLEY ROAD, SUITE 300 SAN DIEGO CA 92121 1 0 0 0 0 Stock Option (right to buy) 2.52 2023-05-17 4 A 0 12000 0.00 A 2033-05-17 Common Stock 12000 12000 D The option, granted pursuant to the Issuer's non-employee director compensation policy, vests in full on the earlier of (i) May 17, 2024 or (ii) the Issuer's 2024 Annual Meeting of Stockholders, subject to the Reporting Person's continued service on the Board of Directors. /s/ Nancy E. Denyes, as Attorney-in-Fact 2023-05-19