X0306 4 2023-02-16 0 0001339970 aTYR PHARMA INC LIFE 0001640869 DENYES NANCY 3545 JOHN HOPKINS COURT, SUITE 250 SAN DIEGO CA 92121 0 1 0 0 General Counsel Employee Stock Option (right to buy) 2.195 2023-02-16 4 A 0 84023 0.00 A 2033-02-16 Common Stock 84023 84023 D The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning March 16, 2023, such that this option will be fully exercisable on February 16, 2027. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer. /s/ Nancy E. Denyes 2023-02-21