X0306 4 2023-02-03 0 0001339970 aTYR PHARMA INC LIFE 0001305178 Broadfoot Jill Marie 3545 JOHN HOPKINS COURT, SUITE 250 SAN DIEGO CA 92121 0 1 0 0 Chief Financial Officer Common stock 2023-02-03 4 M 0 3750 A 17026 D Common stock 2023-02-06 4 S 0 1566 2.36 D 15460 D Restricted Stock Unit 2023-02-03 4 M 0 3750 0.00 D Common Stock 3750 11250 D Represents shares acquired upon the vesting of restricted stock units (RSUs) granted to the Reporting Person on February 3, 2022. Restricted stock units convert into common stock on a one-for-one basis. Includes 986 shares acquired under that Company's 2015 Employee Stock Purchase Plan on November 15, 2022. Sale made by the Reporting Person to satisfy tax withholding obligations in connection with the partial vesting of RSUs granted on February 3, 2022. The RSUs vest in four equal annual installments beginning on February 3, 2023, such that the RSUs will fully vest on February 3, 2026. The RSUs are subject to accelerated vesting upon termination without cause upon a change of control of the Issuer. /s/ Nancy E. Denyes, attorney-in-fact 2023-02-06