X0306 4 2022-05-24 0 0001339970 aTYR PHARMA INC LIFE 0001305178 Broadfoot Jill Marie 3545 JOHN HOPKINS COURT, SUITE 250 SAN DIEGO CA 92121 0 1 0 0 Chief Financial Officer Common Stock 12290 D Employee Stock Option (right to buy) 2.81 2022-05-24 4 A 0 75347 0.00 A 2032-05-24 Common Stock 75347 75347 D Includes 178 shares acquired under the Company's 2015 Employee Stock Purchase Plan (ESPP) on May 13, 2022. The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning June 24, 2022, such that this option will be fully exercisable on May 24, 2026. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer. Nancy E. Denyes, attorney-in-fact 2022-05-26