X0306 4 2021-05-21 0 0001339970 aTYR PHARMA INC LIFE 0001305178 Broadfoot Jill Marie 3545 JOHN HOPKINS COURT, SUITE 250 SAN DIEGO CA 92121 0 1 0 0 Chief Financial Officer Common stock 10011 D Employee Stock Option (Right to buy) 4.45 2021-05-21 4 A 0 54000 0.00 A 2025-05-21 Common Stock 54000 54000 D Includes 178 shares acquired under that Company's 2015 Employee Stock Purchase Plan on May 17, 2021. The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning June 21, 2021, such that this option will be fully exercisable on May 21, 2025. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer. Nancy Denyes, attorney-in-fact 2021-05-25