X0306 4 2021-05-21 0 0001339970 aTYR PHARMA INC LIFE 0001671026 Shukla Sanjay 3545 JOHN HOPKINS COURT, SUITE #250 SAN DIEGO CA 92121 1 1 0 0 President and CEO Employee Stock Option (Right to buy) 4.45 2021-05-21 4 A 0 207000 0.00 A 2025-05-21 Common Stock 207000 207000 D The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning June 21, 2021, such that this option will be fully exercisable on May 21, 2025. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer. Nancy Denyes, attorney-in-fact 2021-05-25