X0306 4 2021-05-21 0 0001339970 aTYR PHARMA INC LIFE 0001602225 Zaknoen Sara 3545 JOHN HOPKINS CT. SUITE 250 SAN DIEGO CA 92121 1 0 0 0 Stock Option (right to buy) 4.45 2021-05-21 4 A 0 2285 0.00 A 2031-05-21 Common Stock 2285 2285 D The shares subject to this option shall vest and become exercisable in 36 equal monthly installments beginning June 21, 2021, such that this option will be fully exercisable on May 21, 2024, subject to the recipient's continued service on the Issuer's Board of Directors. Nancy Denyes, Attorney-In-Fact 2021-05-25