X0306 4/A 2021-02-04 2021-02-08 0 0001339970 aTYR PHARMA INC LIFE 0001671026 Shukla Sanjay 3545 JOHN HOPKINS COURT, SUITE #250 SAN DIEGO CA 92121 1 1 0 0 President and CEO Employee Stock Option (right to buy) 4.52 2021-02-04 4 A 0 112469 0.00 A 2031-02-04 Common Stock 112469 112469 D The option grant was originally intended for 120,000 shares. However, that size of grant was in excess of an annual grant limit in the Issuer's equity plan and, as a result, the portion of the award that was in excess of the plan limit was disgorged. The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning March 4, 2021, such that this option will be fully exercisable on February 4, 2025. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer. Nancy E. Denyes, attorney-in-fact 2021-03-09