X0306 4 2021-02-04 0 0001339970 aTYR PHARMA INC LIFE 0001305178 Broadfoot Jill Marie 3545 JOHN HOPKINS COURT, SUITE 250 SAN DIEGO CA 92121 0 1 0 0 Chief Financial Officer Employee Stock Option (right to buy) 4.52 2021-02-04 4 A 0 50000 0.00 A 2031-02-04 Common Stock 50000 50000 D The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning March 4, 2021, such that this option will be fully exercisable on February 4, 2025. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer. Nancy E. Denyes, attorney-in-fact 2021-02-08