X0306 4 2016-01-04 0 0001339970 aTYR PHARMA INC LIFE 0001238362 MENDLEIN JOHN 3545 JOHN HOPKINS COURT, SUITE 250 SAN DIEGO CA 92121 1 1 0 0 CEO and Director Employee Stock Option (right to buy) 9.13 2016-01-04 4 A 0 148732 0.00 A Common Stock 148732 148732 D The shares subject to this option shall vest and become exercisable, if at all, in 48 equal monthly installments upon the achievement of certain performance goals, which must be achieved by January 4, 2018, or such option will be subject to immediate forfeiture. This option is subject to accelerated vesting upon termination without cause upon a change of control of the Issuer. /s/ Nancy Krueger, as Power of Attorney 2016-01-06