X0306 4 2015-10-01 0 0001339970 aTYR PHARMA INC LIFE 0001640869 Krueger Nancy 3545 JOHN HOPKINS COURT, SUITE 250 SAN DIEGO CA 92121 0 1 0 0 VP, Legal Affairs Employee Stock Option (right to buy) 10.24 2015-10-01 4 A 0 17000 0.00 A 2025-10-01 Common Stock 17000 17000 D Employee Stock Option (right to buy) 10.24 2015-10-01 4 A 0 4739 0.00 A Common Stock 4739 4739 D The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning on November 1, 2015, such that this option will be fully exercisable on October 1, 2019. This option is subject to accelerated vesting upon termination without cause upon a change of control of the Issuer. The shares subject to this option shall vest and become exercisable, if at all, in 48 equal monthly installments upon the achievement of certain performance goals, which must be achieved by October 1, 2017, or such option will be subject to immediate forfeiture. This option is subject to accelerated vesting upon termination without cause upon a change of control of the Issuer. /s/ Nancy Krueger 2015-10-05