Organization, Business, Basis of Presentation and Summary of Significant Accounting Policies - Additional Information (Detail) $ / shares in Units, $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2025 USD ($) Segment $ / shares shares	Mar. 31, 2024 USD ($)	Dec. 31, 2024 USD ($) $ / shares shares	Dec. 31, 2023 USD ($)
Description Of Business [Line Items]
Net Income (Loss)	$ (14,880)	$ (15,491)
Accumulated deficit	(546,926)		$ (532,046)
Cash, cash equivalents, available-for-sale investments and restricted cash	78,800
Restricted cash	2,432	$ 3,214	$ 2,951
Employee retention of payroll expenses				$ 1,200
Employee retention credit benefits refund received	$ 1,000
Number of operating segment | Segment	1
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description	Our CODM is our Chief Executive Officer, who reviews and evaluates consolidated research and development expenses, general and administrative expenses, net loss, net cash used in operating activities and our consolidated cash and cash equivalents for purposes of making operating decisions, allocating resources and planning and forecasting future periods.
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]	srt:ChiefExecutiveOfficerMember
Research and Development Expense [Member]
Description Of Business [Line Items]
Employee retention credit receivable - research and development expenses				800
General and Administrative Expense [Member]
Description Of Business [Line Items]
Employee retention credit receivable - general and administrative expenses				$ 400
Jefferies LLC [Member] | ATM Offering Program [Member]
Description Of Business [Line Items]
Shares issued, price per share | $ / shares	$ 3.93		$ 2.02
Proceeds from issuance of common stock, net of offering costs	$ 18,800		$ 40,300
Jefferies LLC [Member] | Common Stock [Member] | ATM Offering Program [Member]
Description Of Business [Line Items]
Number of shares issued and sold | shares	4,941,895		20,653,450
Accounting Standards Update 2023-09 [Member]
Description Of Business [Line Items]
Change in accounting principle, accounting standards update, adopted	true
Change in accounting principle, accounting standards update, adoption date	Jan. 01, 2025
Change in accounting principle, accounting standards update, immaterial effect	true
Accounting Standards Update 2024-03 [Member]
Description Of Business [Line Items]
Change in accounting principle, accounting standards update, early adoption	true
Pangu BioPharma [Member] | Hong Kong [Member]
Description Of Business [Line Items]
Majority-owned subsidiary percentage	98.00%