September 12, 2019

Raj Kannan
Chief Executive Officer
Chiasma, Inc.
460 Totten Pond Road, Suite 530
Waltham, Massachusetts 02451

       Re: Chiasma, Inc.
           Registration Statement on Form S-3
           Filed September 6, 2019
           File No. 333-233654

Dear Mr. Kannan:

       We have limited our review of your registration statement to those
issues we have
addressed in our comment.

       Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe our comment applies to your facts
and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information you
provide in response to this comment, we may have additional comments.

Registration Statement on Form S-3 filed September 6, 2019

Description of Capital Stock, page 10

1.     We note that your forum selection provision identifies the Court of
Chancery of the State
       of Delaware as the exclusive forum for certain litigation, including any
"derivative
       action." Please revise your disclosure to clarify whether this provision
applies to actions
       arising under the Securities Act or Exchange Act. In that regard, we
note that Section 27
       of the Exchange Act creates exclusive federal jurisdiction over all
suits brought to enforce
       any duty or liability created by the Exchange Act or the rules and
regulations thereunder,
       and Section 22 of the Securities Act creates concurrent jurisdiction for
federal and state
       courts over all suits brought to enforce any duty or liability created
by the Securities Act
       or the rules and regulations thereunder. If the provision applies to
Securities Act claims,
       please also revise your prospectus to specifically state that there is
uncertainty as to
       whether a court would enforce such provision and that investors cannot
waive compliance
 Raj Kannan
Chiasma, Inc.
September 12, 2019
Page 2
       with the federal securities laws and the rules and regulations
thereunder. If this provision
       does not apply to actions arising under the Securities Act or Exchange
Act, please tell us
       how you will inform investors in future filings that the provision does
not apply to any
       actions arising under the Securities Act or Exchange Act.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Irene Paik at 202-551-6553 or Mary Beth Breslin at
202-551-3625 with
any questions.



                                                              Sincerely,
FirstName LastNameRaj Kannan
                                                              Division of
Corporation Finance
Comapany NameChiasma, Inc.
                                                              Office of
Healthcare & Insurance
September 12, 2019 Page 2
cc:       Daniel A. Lang - Goodwin Procter LLP
FirstName LastName