Equity Incentive Plans, Stock Option Plan, Activity (Details) - 2021 Employee Stock Purchase Plan [Member] - USD ($)	3 Months Ended
Mar. 31, 2022	Dec. 31, 2021
Number of Options [Roll Forward]
Beginning balance (in shares)	689,995
Granted (in shares)	270,170
Expired (in shares)	(3,334)
Forfeited (in shares)	(834)
Ending balance (in shares)	955,997
Weighted Average Exercise Price [Abstract]
Beginning balance (in dollars per share)	$ 3.58
Granted (in dollars per share)	6.71
Expired (in dollars per share)	27.00
Forfeited (in dollars per share)	6.12
Ending balance (in dollars per share)	$ 4.38
Option outstanding [Abstract]
Weighted average remaining contracted term in years	6 years 5 months 19 days
Aggregate intrinsic value	$ 125,279	$ 683,531
Options vested and exercisable [Abstract]
Options vested and exercisable, Number of option vested (in shares)	529,027
Options vested and exercisable, Exercise price (in dollars per share)	$ 3.65
Options vested and exercisable, Weighted average remaining life years	5 years 2 months 15 days
Option vested, Aggregate intrinsic value	$ 64,168
Estimated Fair Value Assumptions [Abstract]
Exercised (in shares)	0
Employee [Member]
Number of Options [Roll Forward]
Granted (in shares)	253,170
Weighted Average Exercise Price [Abstract]
Ending balance (in dollars per share)	$ 6.96
Options vested and exercisable [Abstract]
Fair values of options granted (in dollars per share)	$ 2.34
Estimated Fair Value Assumptions [Abstract]
Expected term (in years)	6 years 5 months 19 days
Risk free interest rate	1.74%
Dividend yield	0.00%
Expected volatility	107.23%
Employee [Member] \| Performance Based Options [Member]
Number of Options [Roll Forward]
Granted (in shares)	140,000
Nonemployee [Member]
Number of Options [Roll Forward]
Granted (in shares)	17,000
Weighted Average Exercise Price [Abstract]
Ending balance (in dollars per share)	$ 3.03
Options vested and exercisable [Abstract]
Fair values of options granted (in dollars per share)	$ 2.49
Estimated Fair Value Assumptions [Abstract]
Expected term (in years)	6 years
Risk free interest rate	1.64%
Dividend yield	0.00%
Expected volatility	107.78%

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Gross number of share options (or share units) granted during the period.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options of the plan that expired.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for fully vested and expected to vest options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of share options (or share units) exercised during the current period.

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