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Income Taxes, Statutory Federal Income Tax Rate and Income Taxes (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Reconciliation of Income Tax (Benefit) Expense [Abstract]    
Federal income tax at statutory federal rate 21.00% 21.00%
Permanent differences 2.00% (1.00%)
Research and development credit 3.00% 3.00%
Other deferred adjustments 0.00% (5.00%)
State income tax expense (net of federal benefit) 1.00% 1.00%
Valuation allowance (27.00%) (19.00%)
Effective tax rate 0.00% 0.00%