X0303 4 2011-01-08 0 0001107421 ZIOPHARM ONCOLOGY INC ZIOP 0001338532 LEWIS JONATHAN 1180 AVENUE OF THE AMERICAS, 19TH FLOOR NEW YORK NY 10036 1 1 0 0 CEO Common Stock, $.001 par value 450 I By Children Common Stock, $.001 par value 2011-01-08 4 F 0 15190 5.14 D 479510 D Stock Option (right to buy) 0.08 2007-01-08 2014-01-08 Common Stock 25674 25674 D Stock Option (right to buy) 0.08 2007-01-27 2014-01-27 Common Stock 242979 242979 D Stock Option (right to buy) 4.31 2007-01-27 2015-06-08 Common Stock 87789 87789 D Stock Option (right to buy) 4.31 2007-01-27 2015-09-13 Common Stock 54161 54161 D Stock Option (right to buy) 5.01 2006-04-26 2016-04-26 Common Stock 139315 139315 D Stock Option (right to buy) 5.01 2006-04-26 2016-04-26 Common Stock 75000 75000 D Stock Option (right to buy) 6.49 2016-12-13 Common Stock 30000 30000 D Stock Option (right to buy) 4.85 2017-06-18 Common Stock 35000 35000 D Stock Option (right to buy) 2.73 2017-12-12 Common Stock 100000 100000 D Stock Option (right to buy) 0.70 2019-05-13 Common Stock 100000 100000 D Stock Option (right to buy) 2.85 2019-12-31 Common Stock 150000 150000 D Stock Option (right to buy) 4.77 2020-12-31 Common Stock 150000 150000 D 10,000 shares vest on each of 12/13/07, 12/13/08 and 12/13/09. 11,667 shares vest on each of 6/18/08 and 6/18/09; 11,666 shares vest on 6/18/10. 33,334 shares vest on 12/12/08; 33,333 shares vest on each of 12/12/09 and 12/12/10. 25,000 shares vest immediately, 25,000 shares vest on each of 8/13/2009, 11/13/2009 and 2/13/2010. By the Reporting Person as custodian for his minor children under the Connecticut Uniform Gifts to Minors Act. Disposition represents shares forfeited to satisfy withholding tax obligations upon the vesting of a restricted stock grant. 50,000 shares vest on each of 12/31/2010, 12/31/2011 and 12/31/2012. 50,000 shares vest on each of 12/31/2011, 12/31/2012 and 12/31/2013. Exhibit 24 attached hereto. /s/ Richard E. Bagley, as Attorney-in-Fact for Jonathan Lewis 2011-01-10