Condensed Consolidated Statements of Operations - USD ($) shares in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Statement [Abstract]
Net product sales	$ 239,887,000	$ 158,373,000	$ 48,546,000
Cost of product sales	52,332,000	14,370,000	5,019,000
Operating Expenses:
Selling, general and administrative	187,879,000	132,715,000	76,082,000
Research and development	44,862,000	37,990,000	29,792,000
Total operating expenses	232,741,000	170,705,000	105,874,000
Loss from operations	(45,186,000)	(26,702,000)	(62,347,000)
Interest expense, net	(27,605,000)	(9,691,000)	(453,000)
Other income (expense), net	1,221,000	(2,093,000)	(211,000)
Loss before provision for income taxes	(71,570,000)	(38,486,000)	(63,011,000)
Provision for income taxes	(1,769,000)	(899,000)	(347,000)
Net loss	$ (73,339,000)	$ (39,385,000)	$ (63,358,000)
Net loss per common share - basic and diluted	$ (2.55)	$ (1.35)	$ (2.19)
Weighted-average common shares outstanding - basic and diluted	28,712	29,079	28,883