Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Total revenues, net	$ 27,185	$ 18,033	$ 50,155	$ 38,374
Costs and expenses:
Cost of goods sold	6,177	7,326	12,877	13,418
Selling, general and administrative	34,542	33,237	67,140	70,139
Pre-approval commercial manufacturing	0	80	0	2,194
Research and development	17,967	19,943	35,858	39,116
Total costs and expenses	58,686	60,586	115,875	124,867
Loss from operations	(31,501)	(42,553)	(65,720)	(86,493)
Other (expense) income, net	(7,169)	(5,634)	(14,883)	(10,856)
Loss before income taxes	(38,670)	(48,187)	(80,603)	(97,349)
Income tax expense (benefit)	18	0	49	(33)
Net loss	$ (38,688)	$ (48,187)	$ (80,652)	$ (97,316)
Net loss per common share—basic (in dollars per share)	$ (0.84)	$ (1.05)	$ (1.75)	$ (2.12)
Net loss per common share—diluted (in dollars per share)	$ (0.84)	$ (1.05)	$ (1.75)	$ (2.12)
Weighted average number of common shares outstanding—basic (in shares)	46,197,656	45,876,106	46,153,613	45,834,305
Weighted average number of common shares outstanding—diluted (in shares)	46,197,656	45,876,106	46,153,613	45,834,305
Net loss	$ (38,688)	$ (48,187)	$ (80,652)	$ (97,316)
Unrealized gain (loss) on available-for-sale investments, net	3	237	(9)	209
Comprehensive loss	$ (38,685)	$ (47,950)	$ (80,661)	$ (97,107)
Revenue from Contract with Customer, Product and Service [Extensible Enumeration]	Product revenues, net	Product revenues, net	Product revenues, net	Product revenues, net
Product revenues, net
Total revenues, net	$ 27,185	$ 18,033	$ 50,155	$ 38,374