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Stock-Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation Expense
Stock-based compensation expense for options granted, restricted stock awards (“RSAs”), RSAs with non-market performance and service conditions (“PSAs”), restricted stock units (“RSUs”) and stock appreciation rights (“SARs”) is reflected in the condensed consolidated statements of operations and comprehensive loss as follows:
 THREE MONTHS ENDED 
JUNE 30,		SIX MONTHS ENDED 
JUNE 30,
(in thousands)2021202020212020
Cost of goods sold$431 $670 $938 $1,167 
Selling, general and administrative5,598 6,900 11,853 13,808 
Pre-approval commercial manufacturing— 22 — 316 
Research and development1,967 2,584 3,954 5,414 
Total$7,996 $10,176 $16,745 $20,705 
Schedule of Stock Options Activity
The following table summarizes the stock option activity under the Plans:
NUMBER OF
SHARES		WEIGHTED
 AVERAGE EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
Options outstanding at December 31, 2020
8,588,614 $27.36 
Granted605,896 17.33 
Exercised(90,930)3.30 
Canceled(382,930)37.65 
Options outstanding at June 30, 2021
8,720,650 $26.46 5.7$18,969 
Options exercisable at June 30, 2021
6,625,447 $26.81 4.8$18,131 
Schedule of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity
The following table summarizes the RSA activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Non-vested RSAs at December 31, 2020
809,527 $29.03 
Granted116,270 17.40 
Vested(175,336)42.43 
Canceled(58,281)22.94 
Non-vested RSAs at June 30, 2021
692,180 $24.19 
The following table summarizes the RSU activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Non-vested RSUs at December 31, 2020
107,182 $14.43 
Granted4,075 17.32 
Vested(11,146)19.25 
Canceled(3,369)14.08 
Non-vested RSUs at June 30, 2021
96,742 $14.01 
Schedule of Stock Appreciation Rights
The following table summarizes the SAR activity under the Plans:
NUMBER OF
SHARES		WEIGHTED 
AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
SARs outstanding at December 31, 2020
212,044 $32.28 
Granted12,000 18.00 
Canceled(26,013)30.50 
SARs outstanding at June 30, 2021
198,031 $31.64 3.1$161 
SARs exercisable at June 30, 2021
71,028 $44.67 2.3$4