Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Total revenues, net	$ 22,970	$ 20,341
Costs and expenses:
Cost of goods sold	6,700	6,092
Selling, general and administrative	32,598	36,902
Pre-approval commercial manufacturing	0	2,114
Research and development	17,891	19,173
Total costs and expenses	57,189	64,281
Loss from operations	(34,219)	(43,940)
Other (expense) income, net	(7,714)	(5,222)
Loss before income taxes	(41,933)	(49,162)
Income tax expense (benefit)	31	(33)
Net loss	$ (41,964)	$ (49,129)
Net loss per common share—basic and diluted (in dollars per share)	$ (0.91)	$ (1.07)
Weighted average number of common shares outstanding—basic and diluted (in shares)	46,109,080	45,792,504
Net loss	$ (41,964)	$ (49,129)
Unrealized loss on available-for-sale investments, net	(12)	(28)
Comprehensive loss	(41,976)	(49,157)
Product revenues, net
Total revenues, net	$ 22,970	$ 20,341